|
Category:
|
Neuroimmunology
|
|
Test Code:
|
456 |
|
Disease:
|
Neuropathies |
|
Methodology:
|
Indirect Immunofluorescence |
|
Substrate:
|
Substrate: Primate Peripheral Nerve/Bovine Optic Nerve |
|
Reference Range:
|
Negative: <1:10 |
|
Units:
|
Units: Titer |
|
Note:
|
Note: Positive IFA samples are confirmed by Western Blot at an additional charge. |
|
CPT Code:
|
CPT Code: 86255 |
|
Schedule / Turnaround Time:
|
Schedule/Turnaround Time: Assay performed daily Monday-Friday. Report availability is within 48 hours from the time of specimen receipt. |
|
Specimen Requirements:
|
Specimen need not be refrigerated or frozen. Collect 2-3 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into white tube provided with Immco Diagnostics’ collection kits. If separation facilities are not available, the blood can be sent in the tube used for collection. |
|
Sample Stability:
|
Sample Stability: Sample is stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8˚C) up to five days and frozen (-20˚C or lower) up to one year. |
|
Relevance:
|
Clinical Relevance: Neuropathies associated with anti-MAG are often slowly progressive with evidence of demyelination and a variable degree of axonal loss associated with gait ataxia. 50% of all peripheral neuropathy cases with IgM paraproteinemia possess anti-MAG antibodies. Detection of anti-MAG autoantibodies is useful, as it suggests active demyelination in a peripheral neuropathy.Clinical Relevance: Neuropathies associated with anti-MAG are often slowly progressive with evidence of demyelination and a variable degree of axonal loss associated with gait ataxia. 50% of all peripheral neuropathy cases with IgM paraproteinemia possess anti-MAG antibodies. Detection of anti-MAG autoantibodies is useful, as it suggests active demyelination in a peripheral neuropathy.Clinical Relevance: Neuropathies associated with anti-MAG are often slowly progressive with evidence of demyelination and a variable degree of axonal loss associated with gait ataxia. 50% of all peripheral neuropathy cases with IgM paraproteinemia possess anti-MAG antibodies. Detection of anti-MAG autoantibodies is useful, as it suggests active demyelination in a peripheral neuropathy.Clinical Relevance: Neuropathies associated with anti-MAG are often slowly progressive with evidence of demyelination and a variable degree of axonal loss associated with gait ataxia. 50% of all peripheral neuropathy cases with IgM paraproteinemia possess anti-MAG antibodies. Detection of anti-MAG autoantibodies is useful, as it suggests active demyelination in a peripheral neuropathy. |