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ANA-AMA-SMA-PCA Double Sec.
Technology : IFA ~ Autoimmune IFA Screen Brand : MarDx® ~ Autoimmune IFA Screen Analyte : Autoimmune ~ Systemic Rheumatoid Diseases Intended UseThe detection, differentiation and quantitation of circulating autoimmune antibodies in human serum utilizing indirect immunofluorescence (IFA).PrincipleANA antibodies are not organ or species specific.(6) The primary test reaction involves circulating antinuclear antibodies present in the patients serum which attach to their homologous nuclear antigens. This occurs during the incubation period while the serum covers the antigen surface. A secondary reaction then follows a rinsing period which removes all unbound human antibody. The reagent used in the secondary reaction is a fluorescein labeled anti-human globulin conjugate. The antigen surface is then thoroughly rinsed free of unbound onjugate and viewed under an appropriate fluorescent microscope for various morphological patterns of nuclear fluorescence which can be visually identified. (10) The clinical significance of the various nuclear immunofluorescent patterns is useful in evaluating patients for the presence of the connective tissue diseases. The homogeneous pattern is the most common pattern and is associated with SLE. The peripheral pattern confirms a clinical diagnosis of SLE. True speckled nuclear fluorescence is seen in Scleroderma, Raynaud's disease, Rheumatoid Arthritis, and Sjogren's syndrome. Nucleolar fluorescence is seen mainly in Scleroderma and Sjogren's syndrome.Product Code : 10-2396 Format : Mardx 8 wells Test/Kit : 96 tests FDA : Cleared CE : Cleared Additional Information : Insert Version : MDN 04-0028eng rev 6
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